The Bessman lab is interested in the interplay between the immune system and intestinal bacteria during health and disease. We recently discovered that the immune system carefully regulates iron levels to contain and control intestinal bacteria. In ongoing work, we aim to better understand how the immune system promotes colonization by specific bacterial species that promote human health. We are developing cutting edge in vivo models using genetically modified mice and bacteria to address these questions, with the long-term goal of developing new therapeutic strategies for treating disease.