Research in the Beaulieu Lab is focused on understanding the molecular and cellular signals that regulate immune responses by Natural Killer (NK) cells and “helper” innate lymphoid cells (ILC1s). We use a broad range of genetic, cellular, and molecular tools to identify and interrogate novel pathways that contribute to NK cell development, differentiation, and effector responses at steady-state and in settings of infection and other inflammatory processes such as pregnancy, injury, and cancer. Ongoing projects in our lab include investigation of molecular pathways that regulate: (1) antigen-specific effector and memory responses by NK cells during viral infection; (2) differentiation and function of unique tissue-resident NK cell and ILC1 populations in tissues such as the uterus and skin; (3) anti-tumor responses by NK cells; and (4) NK cell-mediated modulation of other immune and non-immune cell types in infected or inflamed tissues.
- Title
- Assistant Professor and Chancellor Scholar
- Area of Study/Expertise
- Reproductive Immunology
- ab1550@njms.rutgers.edu