Dr. Jack Chun-Chieh Hsu received his Ph.D. from the Department of Biochemistry at Duke University. His research focused on elucidating the complex life of RNA in RNA localization and translational regulation, investigating the dual-function membrane proteins moonlighting as RNA-binding proteins on the endoplasmic reticulum. Dr. Hsu’s academic journey continued in the Department of Immunobiology at Yale University, where he studied the molecular mechanism by which the antiviral protein viperin inhibits viral replication through translation inhibition. Since the outbreak of the COVID-19 pandemic, Dr. Hsu has been focusing on diagnostic testing, host antiviral responses, viral immune evasion, and studying the biology of SARS-CoV-2. His research led to the identification of a novel SARS-CoV-2 translation inhibitory protein (NSP14), responsible for suppressing host translation and subverting the interferon antiviral response. Dr. Hsu’s long-term research interests include understanding the molecular arms race between host and virus, as they regulate the translation machinery to establish either an antiviral or pro-viral state. His lab also translates these findings into innovative approaches for developing antivirals and biomarkers.
- Title
- Associate Professor
- jack.hsu@rutgers.edu