The Parker lab investigates host-pathogen interactions in the context of bacterial infection. We currently work with the bacterium, Staphylococcus aureus, a major human pathogen responsible for a broad range of diseases including pneumonia, bloodstream and skin and soft tissue infections. We investigate the interaction of S. aureus with the host innate immune system, covering the fields of bacterial pathogenesis and innate immunity. Our more immunological studies look at innate immune cell function and development, and innate immune memory and how this impacts bacterial infection. Our studies take a multi-disciplinary approach that includes both in vitro and in vivo techniques that span microbiology, immunology, cell biology and molecular biology.