The overall research focus of our lab is to answer the important question of how coronaviruses cause disease. We aim to address this question by dissecting and understanding the process of pathogenesis and disease progression after coronavirus infection. We use various virology and immunology approaches to investigate virus- and immune (host)-mediated pathogenesis in various model systems. We are particularly interested in coronavirus-host interactions and how these interactions affect overall disease outcome. Another major direction of our lab is to develop cell and animal models for coronavirus infection. Robust and reliable models are not only critical to answer basic scientific questions but also essential for vaccine and antiviral development.
Faculty Profile