The Neiditch lab uses diverse methods including biochemical, genetic, computational, and biophysical (mainly X-ray crystallographic and cryo-EM) techniques to study fundamentally important and broadly conserved cellular processes in bacteria. The basic science research in the Neiditch lab encompasses structure-function studies of the following areas, among others: oligopeptide- and small molecule-mediated bacterial cell-cell communication; bacterial cytidine deaminases in phage defense; second messenger signal transduction; phosphorelay signal transduction; transcriptional activators/repressors/anti-activators; and genetic transformation machinery. The translational work in the Neiditch lab focuses on developing inhibitors of Mycobacterium tuberculosis mycolic acid biosynthesis and respiration; developing broad-spectrum inhibitors of bacterial biofilm growth and cell-cell communication; and structure-function studies of cytidine deaminases in health and disease.
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- Professor
- neiditmb@njms.rutgers.edu